PARKINSON'S DISEASE AND DEPRESSION
Identifieur interne : 002949 ( Main/Exploration ); précédent : 002948; suivant : 002950PARKINSON'S DISEASE AND DEPRESSION
Auteurs : Ann E. Taylor [Canada] ; Jean A. Saint-Cyr [Canada] ; Anthony E. Lang [Canada] ; Frank T. Kenny [Canada]Source :
- Brain [ 0006-8950 ] ; 1986-04.
Abstract
The possibility of an ‘organically’ based depression intrinsic to the pathophysiology of Parkinson's disease (PD) and comparable to endogenous depression (Major Depressive Episode) has been raised. It has also been argued that signs of depression observed in PD are merely the natural reaction of the patients to their progressive and inevitable physical limitations and loss of independent function Because conventional depression rating scales are limited in scope, a psychometric investigation of depression in PD was pursued Based on the known impairment of short-term memory (STM) in endogenous depression, which was confirmed in a group of psychiatric patients in the present study, measures of STM were also obtained in groups of depressed and nondepressed PD patients and in 15 normal control subjects. Regardless of depression severity, PD patients performed as well as control subjects and both these groups consistently obtained scores significantly better than those of the endogenously depressed patients A relative weakness in the PD patients on order-dependent STM tests was further explored and interpreted as an indication of mild frontal lobe dysfunction It was concluded that PD patients are frequently depressed when confronted with their behavioural limitations and that this reaction may be exacerbated by a form of emotional lability related to pathophysiological processes which may involve prefrontal cortical areas.
Url:
DOI: 10.1093/brain/109.2.279
Affiliations:
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Taylor</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Playfair Neuroscience Unit, University of Toronto Ontario</wicri:regionArea><wicri:noRegion>University of Toronto Ontario</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Departments of Psychology and Medicine, University of Toronto Ontario</wicri:regionArea><wicri:noRegion>University of Toronto Ontario</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Institute of Medical Science, University of Toronto Ontario</wicri:regionArea><wicri:noRegion>University of Toronto Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Saint Cyr, Jean A" sort="Saint Cyr, Jean A" uniqKey="Saint Cyr J" first="Jean A." last="Saint-Cyr">Jean A. Saint-Cyr</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Playfair Neuroscience Unit, University of Toronto Ontario</wicri:regionArea><wicri:noRegion>University of Toronto Ontario</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Departments of Psychology and Medicine, University of Toronto Ontario</wicri:regionArea><wicri:noRegion>University of Toronto Ontario</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Departments of Anatomy, University of Toronto Ontario</wicri:regionArea><wicri:noRegion>University of Toronto Ontario</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Institute of Medical Science, University of Toronto Ontario</wicri:regionArea><wicri:noRegion>University of Toronto Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E." last="Lang">Anthony E. 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Kenny</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Playfair Neuroscience Unit, University of Toronto Ontario</wicri:regionArea><wicri:noRegion>University of Toronto Ontario</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Departments of Psychology and Medicine, University of Toronto Ontario</wicri:regionArea><wicri:noRegion>University of Toronto Ontario</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Brain</title><idno type="ISSN">0006-8950</idno><idno type="eISSN">1460-2156</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="1986-04">1986-04</date><biblScope unit="volume">109</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="279">279</biblScope><biblScope unit="page" to="292">292</biblScope></imprint><idno type="ISSN">0006-8950</idno></series><idno type="istex">DC03D195467685BC8596CFEA1F4780F574A5A090</idno><idno type="DOI">10.1093/brain/109.2.279</idno><idno type="ArticleID">109.2.279</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0006-8950</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">The possibility of an ‘organically’ based depression intrinsic to the pathophysiology of Parkinson's disease (PD) and comparable to endogenous depression (Major Depressive Episode) has been raised. It has also been argued that signs of depression observed in PD are merely the natural reaction of the patients to their progressive and inevitable physical limitations and loss of independent function Because conventional depression rating scales are limited in scope, a psychometric investigation of depression in PD was pursued Based on the known impairment of short-term memory (STM) in endogenous depression, which was confirmed in a group of psychiatric patients in the present study, measures of STM were also obtained in groups of depressed and nondepressed PD patients and in 15 normal control subjects. Regardless of depression severity, PD patients performed as well as control subjects and both these groups consistently obtained scores significantly better than those of the endogenously depressed patients A relative weakness in the PD patients on order-dependent STM tests was further explored and interpreted as an indication of mild frontal lobe dysfunction It was concluded that PD patients are frequently depressed when confronted with their behavioural limitations and that this reaction may be exacerbated by a form of emotional lability related to pathophysiological processes which may involve prefrontal cortical areas.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Taylor, Ann E" sort="Taylor, Ann E" uniqKey="Taylor A" first="Ann E." last="Taylor">Ann E. Taylor</name></noRegion><name sortKey="Kenny, Frank T" sort="Kenny, Frank T" uniqKey="Kenny F" first="Frank T." last="Kenny">Frank T. Kenny</name><name sortKey="Kenny, Frank T" sort="Kenny, Frank T" uniqKey="Kenny F" first="Frank T." last="Kenny">Frank T. Kenny</name><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E." last="Lang">Anthony E. Lang</name><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E." last="Lang">Anthony E. Lang</name><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E." last="Lang">Anthony E. Lang</name><name sortKey="Saint Cyr, Jean A" sort="Saint Cyr, Jean A" uniqKey="Saint Cyr J" first="Jean A." last="Saint-Cyr">Jean A. Saint-Cyr</name><name sortKey="Saint Cyr, Jean A" sort="Saint Cyr, Jean A" uniqKey="Saint Cyr J" first="Jean A." last="Saint-Cyr">Jean A. Saint-Cyr</name><name sortKey="Saint Cyr, Jean A" sort="Saint Cyr, Jean A" uniqKey="Saint Cyr J" first="Jean A." last="Saint-Cyr">Jean A. Saint-Cyr</name><name sortKey="Saint Cyr, Jean A" sort="Saint Cyr, Jean A" uniqKey="Saint Cyr J" first="Jean A." last="Saint-Cyr">Jean A. Saint-Cyr</name><name sortKey="Taylor, Ann E" sort="Taylor, Ann E" uniqKey="Taylor A" first="Ann E." last="Taylor">Ann E. Taylor</name><name sortKey="Taylor, Ann E" sort="Taylor, Ann E" uniqKey="Taylor A" first="Ann E." last="Taylor">Ann E. Taylor</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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